The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

Pathogens and inflammatory conditions rapidly induce the expression of immune-
responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate …

Colorectal cancer (CRC) is the third most common diagnosed cancer of which risk factors
include unhealthy diet, smoking, and chronic inflammation. Weakening the inflammatory …

Itaconate is produced from the mitochondrial TCA cycle enzyme aconitase decarboxylase
(encoded by immune responsive gene1; Irg1) that exerts immunomodulatory function in …

Icariin (ICA) is a major bioactive monomer belonging to flavonoid glycosides attracted from
Epimedium, being a classic tonic agent in traditional Chinese medicine. ICA commonly …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Icaritin, an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to
regulate many cellular processes. The purpose of this study was to investigate the protective …

The tricarboxylic acid (TCA) cycle metabolite fumarate nonenzymatically reacts with the
amino acid cysteine to form S-(2-succino) cysteine (2SC), referred to as protein succination …

Immunometabolism is a dynamic process involving the interplay of metabolism and immune
response in health and diseases. Increasing evidence suggests that impaired …

Autacoid local injury antagonist amides (ALIAmides) are a family of endogenous bioactive
acyl ethanolamides that include the renowned palmitoyl ethanolamide (PEA), oleoyl …