Continued elucidation of the mechanisms of brain edema in acute liver failure (ALF) has
established ammonia and the astrocyte as major players in its pathogenesis. The …

A better knowledge of the pathogenesis of brain disturbances in acute-on-chronic liver
failure provides the rationale for using ammonia-focused therapy in the prevention and …

Brain edema and associated increase in intracranial pressure continue to be lethal
complications of acute liver failure (ALF). Abundant evidence suggests that the edema in …

Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure
and circulatory collapse are frequent causes of death, but cerebral edema and intracranial …

Cerebral oedema is a devastating consequence of acute liver failure (ALF) and may be
associated with the development of intracranial hypertension and death. In ALF, some …

Brain edema and the associated increase in intracranial pressure are potentially lethal
complications of acute liver failure (ALF). Astrocyte swelling (cytotoxic edema) represents a …

It is increasingly evident that neuroinflammatory mechanisms are implicated in the
pathogenesis of the central nervous system (CNS) complications (intracranial hypertension …

Neuropathologic investigations in acute liver failure (ALF) reveal significant alterations to
neuroglia consisting of swelling of astrocytes leading to cytotoxic brain edema and …

Acute liver failure (ALF) is characterized neuropathologically by cytotoxic brain edema and
biochemically by increased brain ammonia and its detoxification product, glutamine. The …

Cerebral edema is a potential life-threatening complication in patients with acute liver failure
who progress to grade III/IV encephalopathy. The incidence is variably reported but appears …