Macrophage-derived foam cells are a prominent component of developing atherosclerotic
lesions. We describe an in vitro model of foam cell formation which mimics some aspects of …

Oxidized low density lipoprotein (LDL) is thought to mediate the transformation of
macrophages to cholesterol-rich foam cells. Yet convincing evidence for this process is …

In atherosclerotic lesions of rabbits fed a cholesterol-rich diet, the lipid deposits of foam cells
derived from monocytes, smooth muscle and endothelial cells were studied by physical …

Pure macrophage-derived foam cells (MFC) were isolated from the aortas of rabbits made
atherosclerotic by balloon deendothelialization followed by diet-induced …

A human cell line THP‐1 was differentiated into macrophages expressing the scavenger
receptor for uptake of modified lipoproteins. The cells were exposed to native low‐density …

A possible mechanism for the formation of smooth muscle foam cells in the atherosclerotic
lesion was explored. Cultured macrophages (J774 cell line) were induced to form …

Introduction 3. Nature of lipid in foam cells 4. Sources of cholesterol that accumulates in
foam cells 5. Significance of foam cell formation 5.1. Trapping lipid in lesions versus …

The transformation of monocyte-derived macrophages into lipid-laden foam cells constitutes
a characteristic and crucial event in the development of the earliest atherosclerotic lesions …

A striking characteristic of atherosclerosis is the accumulation of a large amount of lipids,
mainly cholesterol ester, in the arterial wall. Recently, the involvement of macrophages in …

It is generally accepted that the foam cells in atherosclerotic lesions are derived mainly from
monocytes/macrophages. We investigated whether the macrophage-derived foam cells …