Nearly 70% of newly produced B cells express autoreactive antigen receptors and must be
silenced to prevent autoimmunity. Failure of silencing mechanisms is apparent in type 1 …

Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that involves
participation of both CD4+ and CD8+ T cells. Previous studies have demonstrated …

B cell-deficient nonobese diabetic (NOD) mice are protected from the development of
spontaneous autoimmune diabetes, suggesting a requisite role for Ag presentation by B …

While it is generally accepted that T cells are critical for the development of diabetes in the
non‐obese diabetic (NOD) mouse, the precise functions of the CD4+ and CD8+ subsets …

Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell–mediated
autoimmune disease. However, B-cells may also play a critical role in disease …

B-cells are important in the development of type 1 diabetes, but their role is not completely
defined. Although B-cells produce autoantibodies, these are not thought to be pathogenic; …

Autoantibodies have been used as good markers for the prediction of future development of
type 1 diabetes mellitus (T1DM), but are not thought to be pathogenic in this disease. The …

Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that results
from the destruction of insulin secreting β cells by diabetogenic T cells. The time and …

NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an …

It has been established that insulin-dependent diabetes mellitus (IDDM) in nonobese
diabetic (NOD) mice results from a CD4+ and CD8+ T cell–dependent autoimmune process …