We have been examining antigen presentation and the antigen presenting cells (APC s) in
the islets of Langerhans of the non‐obese diabetic (NOD) mouse. The purpose is to identify …

Despite the impressive protection of B cell-deficient (μMT−/−) nonobese diabetic (NOD) mice
from spontaneous diabetes, existence of mild pancreatic islet inflammation in these mice …

In NOD (nonobese diabetic) mice, a model of autoimmune diabetes, various
immunomodulatory interventions prevent progression to diabetes. However, after …

Cytokines such as IL-1α, IL-1β, and IFN-γ have long been implicated in the pathogenesis of
autoimmune diabetes, but the mechanisms through which they promote diabetogenesis …

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …

In the nonobese diabetic (NOD) mouse model of type 1 diabetes, the immune system
recognizes many autoantigens expressed in pancreatic islet β cells. To silence …

Loss of tolerance is considered to be an early event that is essential for the development of
autoimmune disease. In contrast to this expectation, autoimmune (type 1) diabetes develops …

Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to
autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major …

Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective
destruction of insulin-secreting β cells in the pancreatic islets. Although this is a polygenic …

Type 1 diabetes mellitus is caused by the killing of insulin-producing β cells by CD8+ T cells.
The disease progression, which is chronic, does not follow a course like responses to …