Type 1 diabetes development in NOD mice appears to require both CD4+ and CD8+ T cells.
However, there are some situations where it has been suggested that either CD4+ or CD8+ …

Although dogma predicts that under normal circumstances, potentially offensive autoreactive
cells are silenced by mechanisms of immune tolerance, islet antigen–reactive B …

Converging experimental evidence indicates that CD4+ regulatory T cells control
progression of autoimmune insulitis in nonobese diabetic (NOD) mice. Here, we studied the …

The nonobese diabetic (NOD) mouse develops a high incidence of autoimmune diabetes
and is believed to be a good model for insulin-dependent diabetes mellitus (IDDM) in …

At least 20 insulin-dependent diabetes (Idd) loci modify the progression of autoimmune
diabetes in the NOD mouse, an animal model of human type 1 diabetes. The NOD. c3c4 …

In humans and non‐obese diabetic mice (NOD), insulin‐dependent diabetes mellitus
(IDDM) results from a spontaneous T cell‐dependent autoimmune destruction of insulin …

The NOD mouse is an animal model of IDDM that shows many of the characteristics of
human IDDM. It has been proposed that β-cell destruction in IDDM progresses over time in a …

T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated
destruction of pancreatic β-cells. Studies in T1D patients have been limited by the …

The role of B lymphocytes in the pathogenesis of type 1 diabetes in humans is not entirely
evident. These cells are presumed to be important, but this assumption is largely based on …

B cells can serve dual roles in modulating T cell immunity through their potent capacity to
present Ag and induce regulatory tolerance. Although B cells are necessary components for …