The time development of the biodistribution and the hepatotoxicity following peroral
administration of 14C‐acetaminophen (APAP 400 or 800 mg. kg− 1; 1μCi) was …

Temporal variation in metabolism and hepatotoxicity of acetaminophen (APAP) was
examined using male ICR mice. Animals were injected with a single dose of APAP (400 …

Development of resistance to toxic effects of acetaminophen (APAP) was reported in rodents
and humans, though the mechanism is only partially understood. We examined in rats the …

Species-specific differences in the hepatotoxicity of acetaminophen (APAP) have been
shown. To establish a monkey model of APAP-induced hepatotoxicity, which has not been …

The metabonomic approach has been widely used in toxicology to investigate mechanisms
of toxicity. In the present study alterations in the metabolic profiles, monitored by 1H‐NMR …

The leading cause of drug-induced liver injury in the developed world is overdose with N-
acetyl-p-aminophenol (APAP). A comparative metabonomic approach was applied to the …

Acetaminophen (APAP) produces sex-dependent nephrotoxicity and hepatotoxicity in young
adult Sprague-Dawley (SD) rats and age-dependent toxicity in male rats. There is no …

Acetaminophen (APAP) toxicity is responsible for approximately half of all cases of acute
liver failure in the United States. The mouse model of APAP toxicity is widely used to …

In studies designed to simulate a clinical observation in which an individual became tolerant
to normally lethal doses of acetaminophen (APAP), mice were pretreated with increasing …

Context: Acetaminophen (APAP) hepatotoxicity is often studied in primary cultures of
hepatocytes of various species, but there are only few works comparing interspecies …