Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism

A Ciullo, L Li, C Li, K Tsi, C Farrell… - European Heart …, 2024 - academic.oup.com
Abstract Background and Aims Extracellular vesicles (EVs) secreted by cardiosphere-
derived cells exert immunomodulatory effects through the transmission of small non-coding …

Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL‐10 expression and secretion

L Cambier, G de Couto, A Ibrahim… - EMBO Molecular …, 2017 - embopress.org
Cardiosphere‐derived cells (CDC s) reduce myocardial infarct size via secreted
extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage …

microRNA‐454‐mediated NEDD4‐2/TrkA/cAMP axis in heart failure: Mechanisms and cardioprotective implications

Y Wang, W Pan, X Bai, X Wang… - Journal of cellular and …, 2021 - Wiley Online Library
The current study aimed to investigate the mechanism by which miR‐454 influences the
progression of heart failure (HF) in relation to the neural precursor cell expressed …

Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

D Zhu, S Liu, K Huang, J Li, X Mei, Z Li… - European Heart …, 2023 - academic.oup.com
Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis.
Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac …

MicroRNA-221/222 mediates ADSC-exosome-induced cardioprotection against ischemia/reperfusion by targeting PUMA and ETS-1

TC Lai, TL Lee, YC Chang, YC Chen, SR Lin… - Frontiers in Cell and …, 2020 - frontiersin.org
Cardiovascular disease is a major health problem in industrialized and developing countries
and is the leading cause of death and disability. Myocardial ischemia/reperfusion (I/R) …

[HTML][HTML] Long noncoding RNA LUCAT1 enhances the survival and therapeutic effects of mesenchymal stromal cells post-myocardial infarction

Y Tao, Q Liu, R Wu, C Xiao, C Ni, K Wang, W Hu… - … Therapy-Nucleic Acids, 2022 - cell.com
Mesenchymal stromal cell (MSC) transplantation has been a promising therapeutic strategy
for repairing heart tissues post-myocardial infarction (MI). Nevertheless, its therapeutic …

CXCR4-overexpressed exosomes from cardiosphere-derived cells attenuate myocardial ischemia/reperfusion injury by transferring miRNA to macrophages and …

Y Ma, M Su, W Qian, Y Xuan, T Chen… - Cellular and Molecular …, 2023 - cellmolbiol.org
Cardiosphere-derived cells (CDCs) are emerging as ideal candidates for managing cardiac
inflammation, albeit with some limitations. Recent literatures have indicated that exosomes …

Mesenchymal stem cells-derived extracellular vesicles-shuttled microRNA-223-3p suppress lipopolysaccharide-induced cardiac inflammation, pyroptosis, and …

L Pan, B Yan, J Zhang, P Zhao, Y Jing, J Yu… - International …, 2022 - Elsevier
Abstract Introduction Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs)
possess therapeutical potentials in cardiac disorders. We probed into the mechanisms of …

The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis

JK Zhang, Z Zhang, ZA Guo, Y Fu, XJ Chen… - Nutrition, Metabolism …, 2022 - Elsevier
Background and aims The exosomal long noncoding RNAs (lncRNAs) have been reported
to have cardioprotective effects on ischemia-reperfusion (I/R) injury by hindering ferroptosis …

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …