Bone sarcoma as a second malignancy is rare but highly fatal. The present knowledge
about radiation-absorbed organ dose–response is insufficient to predict the risks induced by …

Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years
following treatment for a solid cancer in childhood. Using a cohort study of children treated …

Background: Radiotherapy decreases cancer mortality, but is associated with an increased
incidence of second primary cancers, including osteosarcomas, especially after exposure in …

We estimated the risk of subsequent bone cancer among 9170 patients who had survived
two or more years after the diagnosis of a cancer in childhood. As compared with the …

Abstract Patients and Methods This is a retrospective review of five children with post‐
irradiation bone sarcoma (PIS). Age at PIS onset ranged between 10 and 17 years (median …

Soft tissue sarcoma (STS) is one of the most frequent second primary cancer that occurs
during the first 20 years following treatment for a solid cancer in childhood. Our aim was to …

Currently, approximately 67% of children diagnosed with cancer can be expected to survive
more than 5 years. Among the most significant late effects of cancer therapy is the …

PURPOSE: To determine the long-term effects of radiotherapy (RT) in children treated for
extremity sarcoma. PATIENTS AND METHODS: Between 1964 and 1997, 15 of 33 children …

Purpose: Radiation-induced osteosarcomas (R-OS) have historically been high-grade,
locally invasive tumors with a poor prognosis. The purpose of this study was to perform a …

Radiotherapy is commonly used for treatment of malignant disease. As a consequence of
radiotherapy, an increased risk of developing a second malignant neoplasm has been …