The relative contribution of the two tryptophan hydroxylase (TPH) isoforms, TPH1 and TPH2,
to brain serotonergic system function is controversial. To investigate the respective role of …

Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …

Abstract The serotonin 5-hydroxytryptamine (5-HT) neurotransmitter system contributes to
various physiological and pathological conditions. 5-HT is the first neurotransmitter for which …

Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …

This study surveyed the distribution of tryptophan hydroxylase 2 (TPH2) mRNA, protein, and
enzymatic activity throughout the male Sprague–Dawley rat brain. TPH2 is the genetic …

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain
serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) …

The recent discovery of TPH‐2, a new isoform of tryptophan hydroxylase, the enzyme that
catalyses the transformation of tryptophan into 5‐hydroxytryptophan and the rate‐limiting …

Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …

Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as
a neurotransmitter and in the control of behavioral traits has been largely documented. At …