The present experiments examined the effects of muscarinic cholinergic receptor blockade
in the nucleus accumbens (NAC) and medial prefrontal cortex (MPC) on intravenous …

In previous work we have shown that rats running a straight alley for intravenous (iv) or
intracerebroventricular (icv) injections of cocaine develop an ambivalence about entering …

The rewarding properties of cocaine have been postulated to be regulated, in part, by the
mesolimbic dopamine system. However, the possibility that the rewarding properties of …

The present study was designed to determine whether the muscarinic cholinergic antagonist
scopolamine can prevent the expression and induction of sensitization to the locomotor …

Little is known regarding which neural systems regulate dose-related changes in responses
maintained by self-administered cocaine. This empirical question is important because …

The rewarding properties of cocaine have been postulated to be regulated, in part, by the
mesolimbic dopamine (DA) system. The present study assessed whether adult female …

We have found that dopamine (DA) in the ventral tegmental area (VTA) plays an important
role in cocaine self-administration. DA in the VTA acts at D1-type receptors on the terminals …

The medial prefrontal cortex (mPFC) has been implicated in the development of behavioral
sensitization, which is the progressive enhancement of locomotor activity that occurs with …

Cocaine is believed to exert its psychostimulant effects through activation of the
mesocorticolimbic system. Although the nucleus accumbens, in particular, has been …

The effects of neurotoxic lesions to the medial prefrontal cortex on both the acquisition and
maintenance of intravenous cocaine self-administration were examined. In one experiment …