Rats were trained to self-administer cocaine (1.5 mg/kg iv) under either a fixed ratio (FR) or
progressive ratio (PR) schedule of reinforcement. Following acquisition, bilateral …

Chronic single neuronal recording techniques were applied to investigate the involvement of
the medial prefrontal cortex (mPFC) during cocaine self‐administration in the rat. Rats were …

Recent studies suggest the participation of cholinergic neurons in the brain processes
underlying reinforcement. The involvement of cholinergic neurons in cocaine self …

Rationale Recent studies have suggested that the medial prefrontal cortex (mPFC) plays an
important role in the development of sensitization to cocaine. In particular, a recent report …

The nucleus accumbens, a major component of the ventral striatum, and the dorsal striatum
are primary targets of the mesolimbic dopamine pathway, which is a pathway that plays a …

Rationale Individuals who abuse cocaine have cognitive deficits, particularly in functions
associated with the orbitofrontal cortex. It is not clear to what extent the impact of cocaine on …

Method Adult male Fischer F-344 rats were initially stereotaxically implanted with 22-gauge
guide cannulae into the medial prefrontal cortex (10.05 mm anterior, 0.6 mm from the …

Rats were trained to self-administer intravenous cocaine under a progressive ratio (PR)
schedule of reinforcement. Under this schedule, an increasing number of lever responses …

A novel behaviorally dependent dosing (BDD) schedule was used to examine the
relationship between doses of cocaine self-administered by rats and brain drug levels within …

Extracellular levels of dopamine are increased in response to systemic administration of
cocaine in several brain areas including the nucleus accumbens and medial prefrontal …