Rationale. Several halogenated analogs of benztropine (BZT) have previously been
characterized as potent dopamine (DA) uptake inhibitors with diminished reinforcing effects …

The involvement of cholinergic neurons in the brain processes underlying reinforcement has
been recently demonstrated. This experiment assessed the potential role of cholinergic …

Muscarinic cholinergic receptors are currently receiving renewed interest as viable targets
for treating various psychiatric disorders. Dopaminergic and muscarinic systems interact in …

Environmental cues are thought to play a role in drug craving, leading to the high relapse
rate observed in cocaine abusers. Cocaine‐paired cues can reinstate cocaine‐maintained …

The effect of cocaine, over a dose range of 2–60 mg/kg, ip, on self-stimulation (SS) behavior
was studied in rats with electrodes either in the posterior hypothalamus (PH …

Up to 31 neurons per animal were simultaneously recorded from the medial prefrontal cortex
and nucleus accumbens in 15 rats during iv cocaine self-administration sessions, using a …

The primate striatum is composed of limbic, cognitive, and sensorimotor functional domains.
Although the effects of cocaine have generally been associated with the ventral striatum, or …

Repeated administration of cocaine progressively increases drug-induced locomotor
activity. This study examined the role of dopamine D1-and D2-like receptors in the medial …

To compare neuronal activity within the mesocorticolimbic circuit during the self-
administration of cocaine and heroin, multiple-channel single-unit recordings of spike …

A new approach combining fast-scan cyclic voltammetry with iontophoretic dopamine
delivery was used in freely behaving rats to evaluate the time-course of dopamine uptake …