Liposome encapsulation of doxorubicin (DXR) has been shown to increase the therapeutic
index of the drug in several animal systems. The prevention of peak plasma concentrations …

LOU M/Wsl rats inoculated sc with 104 immunoglobulin immunocytoma cells have a
palpable tumor at Day 17. Doxorubicin (DXR) has been entrapped in negatively charged …

Numerous studies have demonstrated that liposomal encapsulation decreases the life-
threatening chronic and acute toxicities of doxorubicin in the face of unaltered or improved …

The influence of lipid composition on the in vitro and in vivo behavior of doxorubicin (DXR)
containing liposomes (extrusion-multilamellar vesicles) was investigated in order to assess …

We investigated the biodistribution and antitumour activity of doxorubicin (ADM)
encapsulated in liposomes (L‐ADM) after two administrations in tumour bearing mice. The …

The effect of changes in lipid composition on the antitumor activity of doxorubicin (DXR)-
containing liposomes was studied in immunoglobulin solid immunocytoma-bearing Lou/M …

We describe here an improved method of encapsulating doxorubicin in liposomes using
phosphatidylcholine, cholesterol and synthetic tetramyristoyl cardiolipin. With this new …

The purpose of this study was to perform a kinetic analysis of the tissue distribution of
doxorubicin (DXR) and liposomes separately after intravenous administration of DXR …

In this report we review our preclinical studies on the antitumor efficacy of L-DXR, using
negatively charged sonicated vesicles. Animal studies indicate that various L-DXR …

The comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in
cardiolipin liposomes was evaluated in rats at a dose of 6 mg/kg iv Doxorubicin was …