Entry of HIV-1 virions into cells is a complex and dynamic process carried out by envelope
(Env) glycoproteins on the surface of the virion that promote the thermodynamically …

We investigated the effect of receptor mobility on HIV-1 envelope glycoprotein (Env)-
triggered fusion using B16 mouse melanoma cells that are engineered to express CD4 and …

HIV-1 infection requires fusion of viral and cellular membranes in a reaction catalyzed by the
viral envelope proteins gp120 and gp41. We recently reported that efficient HIV-1 particle …

The cytopathic effects of human immunodeficiency virus type 1 (HIV-1) infection are specific
for cells that express the CD4 viral receptor and consist of syncytium formation and single …

The CD4 molecule is an essential receptor for human immunodeficiency virus type 1 (HIV-1)
through high-affinity interactions with the viral external envelope glycoprotein gp120 …

Recent advances in our understanding of the cellular and molecular mechanisms of HIV-1
entry provide the basis for novel therapeutic strategies that prevent viral penetration of the …

Human immunodeficiency virus (HIV) fusion and entry involves sequential interactions
between the viral envelope protein, gp120, cell surface CD4, and a G-protein-coupled …

Background HIV envelope glycoprotein (Env)-mediated fusion is driven by the concerted
coalescence of the HIV gp41 N-helical and C-helical regions, which results in the formation …

Human immunodeficiency virus (HIV) envelope binds CD4 and a chemokine receptor in
sequence, releasing hydrophobic viral gp41 residues into the target membrane. HIV entry …

The membrane fusion process mediated by the gp41 transmembrane envelope glycoprotein
of the human immunodeficiency virus type 1 (HIV-1) was addressed by a flow cytometry …