Other treatments Peripheral effects of cholinergic drugs Central effects of chohnergic drugs
Behavioural tasks and effects Interpretations of the behavioural effects of cholinergic drugs …

A profound loss of cortical cholinergic innervation is a nearlyinvariant feature of advanced
Alzheimer's disease (AD). The temporal course of this lesion and its relationship to other …

Publisher Summary It is 10 years since the formal presentation of the “cholinergic hypothesis
of geriatric memory dysfunction” by Bartus et al., although many elements were already …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

The present paper reviews three types of evidence implicating the role of acetylcholine in
human memory and dementia:(1) neuropathological evidence that the cholinergic …

Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Alzheimer's disease (AD) is the most common form of dementia affecting the elderly
population today; however, there is currently no accurate description of the etiology of this …

The cholinergic hypothesis of Alzheimer's disease (AD) states 1. that cholinergic neurons in
the basal forebrain are severely affected in the course of disease, detectable both …

The hypothesis that the symptomatology of Alzheimer's disease is attributable to cholinergic
dysfunction is supported by postmortem studies that have demonstrated reduced choline …

The cholinergic abnormality in Alzheimer's disease, the most prevalent form of dementia
amongst elderly people, has aroused new interest in the neurochemical pathology of this …