Human defensins

JJ Schneider, A Unholzer, M Schaller… - Journal of molecular …, 2005 - Springer
Antimicrobial peptides are small, cationic, amphiphilic peptides of 12–50 amino acids with
microbicidal activity against both bacteria and fungi. The eukaryotic antimicrobial peptides …

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

JRC García, A Krause, S Schulz… - The FASEB …, 2001 - Wiley Online Library
ABSTRACT β‐Defensins are antibiotic peptides involved in host defense at the epithelial
surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have been …

Recent advances in the research and development of human defensins

H Chen, Z Xu, L Peng, X Fang, X Yin, N Xu, P Cen - Peptides, 2006 - Elsevier
Human defensins are a family of cationic antimicrobial peptides with molecular weights of 4–
5kDa, containing a conserved six disulphide-linked cysteine motif. During the last two …

[HTML][HTML] The human beta-defensin-3, an antibacterial peptide with multiple biological functions

V Dhople, A Krukemeyer, A Ramamoorthy - Biochimica et Biophysica Acta …, 2006 - Elsevier
A group of interesting molecules called defensins exhibit multiple functions but have been
primarily recognized to possess a broad spectrum of antimicrobial activities. Studies have …

Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs

R Bals, X Wang, RL Meegalla, S Wattler… - Infection and …, 1999 - Am Soc Microbiol
One component of host defense at mucosal surfaces is epithelium-derived peptides with
antimicrobial activity called defensins. We describe in this report the isolation and …

Human beta-defensin-2

JM Schröder, J Harder - The international journal of biochemistry & cell …, 1999 - Elsevier
Human beta-defensin-2 (HBD-2) is a cysteine-rich cationic low molecular weight
antimicrobial peptide recently discovered in psoriatic lesional skin. It is produced by a …

Antimicrobial characterization of human β-defensin 3 derivatives

DM Hoover, Z Wu, K Tucker, W Lu… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …

Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity: Its interaction with plasma membranes of Xenopus …

JR García, F Jaumann, S Schulz, A Krause… - Cell and tissue …, 2001 - Springer
Previous studies have shown the implication of β-defensins in host defense of the human
body. The human β-defensins 1 and 2 (hBD-1, hBD-2) have been isolated by biochemical …

Human defensins: synthesis and structural properties

M Pazgier, X Li, W Lu… - Current pharmaceutical …, 2007 - ingentaconnect.com
Defensins are small, β-sheet-rich, cationic peptides found in many organisms. All defensins
have amphiphilic properties, which are central for antimicrobial activities of the proteins. The …

In vitro bactericidal activity of human β-defensin 2 against nosocomial strains

JG Routsias, P Karagounis, G Parvulesku, NJ Legakis… - Peptides, 2010 - Elsevier
Human β-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune
system that serves as antimicrobial molecule. We determined the bactericidal activity of …