Skin is a dynamic and complex organ that relies on the interaction of different cell types,
biomacromolecules and signaling molecules. Injury triggers a cascade of events designed …

Wound healing is a complex biological process that repairs damaged tissues and restores
skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a …

Background Regenerative wound repair is a goal of modern medicine. This is important not
only for the local repair but also for its beneficial effect to systemic physiological processes …

Inflammation, the initiating stage of wound healing, is characterized by increased
endothelial permeability, infiltration of inflammatory cells, and secretion of numerous growth …

Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

Aims Several studies have indicated that insulin that is used in reducing blood glucose is
also affective on wound healing by various mechanisms. To understand the outcomes of …

Abstract Diabetic foot ulcers affect 15–20% of all diabetic patients and remain an important
challenge since the available therapies have limited efficacy and some of the novel …

Insulin signaling defects could lead to insulin resistance in insulin target organs: typically, in
the muscler, liver, and adipose tissue. We have observed that insulin accelerated diabetic …

Introduction The economic cost of wound management has been estimated to be measured
in billions of dollars. Current financial projections indicate that the cost of managing wounds …

Burn wound healing involves a complex set of overlapping processes in an environment
conducive to ischaemia, inflammation and infection costing $7.5 billion/year in the USA …