The majority of orofacial pain is caused by musculoskeletal and neuropathological diseases
related to inflammatory processes that lead even to transcriptional alterations in the …

Background Endogenous pain modulation (EPM) reflects the brain's ability to modulate
incoming nociceptive inputs, and deficient EPM was implicated as a chronic pain …

Purpose. This study quantified the expression of substance P (SP), calcitonin gene‐related
peptide (CGRP), β‐endorphins (β‐End), and methionine‐enkephalin (Met‐Enk) in human …

The pathophysiology of primary burning mouth syndrome (BMS) remains controversial.
Targeted analyses or “omics” approach of saliva provide diagnostic or pathophysiological …

Pain from oral mucositis afflicts from 40% to 70% of patients receiving chemotherapy or
radiation therapy. Current methods of clinical pain management (for example, topical …

Objective (s): Oxytocin is involved in modulation of many brain-mediated functions. In the
present study, we investigated the central effects of oxytocin and its receptor antagonist …

Background: Burning mouth syndrome (BMS) is characterized by an oral burning sensation
(OBS) in the tongue or other oral mucous membrane in the absence of any clinical abnormal …

Introduction: The presence of a temporomandibular disorder is one of the most frequent
causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes …

Background Burning mouth syndrome (BMS) is an oral-facial pain disorder involving the
central and peripheral nervous systems, but the evidence for altered pain sensitivity remains …

Purpose: Experimental inflammation of the rat temporomandibular joint (TMJ) is commonly
used to study trigeminal nociceptive processing. This study describes spontaneous pain …