Objective The aim of this systematic review was to summarize the use of natural products
(NP) in the treatment of orofacial nociception in animal models. Methods Pre-clinical studies …

Objective To assess changes in orofacial tactile sensitivity and gnawing related to capsaicin-
mediated cutaneous, myogenic, and arthrogenic nociception in the rat. Design After …

Background Spicy foods are flavorful and stimulate salivation, which is beneficial for
individuals with poor appetite. They are also ubiquitous in many regional cuisines, but the …

Background The neurochemical background of the evolution of headache disorders, still
remains partially undiscovered. Accordingly, our aim was to further explore the …

Chemesthetic agents consist of chemical compounds known to activate receptors involved
with pain, touch and thermal perception, such as warming, cooling, stinging, pricking …

The aim of this study was to develop a rat model of capsaicin-induced pain in the orofacial
region. We examined the effects of subcutaneous injection of different doses of capsaicin …

Background Transient receptor potential (TRP) cation channels are involved in the
perception of hot and cold pain and are targets for pain relief in humans. We hypothesized …

Background Burning mouth syndrome (BMS) is a chronic and spontaneous oral pain with
burning quality in the tongue or other oral mucosa without any identifiable oral lesion or …

Burning mouth syndrome (BMS) is a chronic condition most common in middle‐aged and
elderly women, with prevalence rates in the general population ranging from 0.5% to 5 …

The pathophysiology of primary burning mouth syndrome (BMS) has been extensively
debated but is poorly understood despite a large number of hypotheses attempting to …