Passive microfluidic devices for cell separation

T Zhang, D Di Carlo, CT Lim, T Zhou, G Tian… - Biotechnology …, 2024 - Elsevier
The separation of specific cell populations is instrumental in gaining insights into cellular
processes, elucidating disease mechanisms, and advancing applications in tissue …

Continuous separation of cells and particles in microfluidic systems

A Lenshof, T Laurell - Chemical Society Reviews, 2010 - pubs.rsc.org
The progress in microfabrication and lab-on-a-chip technologies has been a major area of
development for new approaches to bioanalytics and integrated concepts for cell biology …

Microfluidic‐based approaches in targeted cell/particle separation based on physical properties: fundamentals and applications

R Nasiri, A Shamloo, S Ahadian, L Amirifar, J Akbari… - Small, 2020 - Wiley Online Library
Cell separation is a key step in many biomedical research areas including biotechnology,
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Microfluidic sorting of microtissues

DG Buschke, P Resto, N Schumacher, B Cox… - …, 2012 - pubs.aip.org
Increasingly, invitro culture of adherent cell types utilizes three-dimensional (3D) scaffolds or
aggregate culture strategies to mimic tissue-like, microenvironmental conditions. In parallel …

[HTML][HTML] Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue

X Qiu, JH Huang, TM Westerhof, JA Lombardo… - Scientific reports, 2018 - nature.com
Maximizing the speed and efficiency at which single cells can be liberated from tissues
would dramatically advance cell-based diagnostics and therapies. Conventional methods …

Advances in microfluidic cell separation and manipulation

EL Jackson, H Lu - Current opinion in chemical engineering, 2013 - Elsevier
Highlights•Microfluidics is a powerful tool for bioanalytics and some preparatory
applications.•Many flow and field effects can be miniaturized for separations.•Future …

Microfluidic Label‐Free Hydrodynamic Separation of Blood Cells: Recent Developments and Future Perspectives

S Lee, H Kim, S Yang - Advanced Materials Technologies, 2023 - Wiley Online Library
The biophysical characteristics and counts of blood cells provide useful information
regarding pathological conditions. Therefore, the separation of blood components is a …

Hybrid microfluidics combined with active and passive approaches for continuous cell separation

S Yan, J Zhang, D Yuan, W Li - Electrophoresis, 2017 - Wiley Online Library
Microfluidics, which is classified as either active or passive, is capable of separating cells of
interest from a complex and heterogeneous sample. Active methods utilise external fields …

Translating microfluidics: Cell separation technologies and their barriers to commercialization

CW Shields IV, KA Ohiri, LM Szott… - Cytometry Part B …, 2017 - Wiley Online Library
Advances in microfluidic cell sorting have revolutionized the ways in which cell‐containing
fluids are processed, now providing performances comparable to, or exceeding, traditional …