Although inflammatory responses are a critical component in defense against pathogens,
too much inflammation is harmful. Mechanisms have evolved to regulate inflammation …

Taste buds are chemosensory structures widely distributed on the surface of the oral cavity
and larynx. Taste cells, exposed to the oral environment, face great challenges in defense …

Background The mammalian taste bud, a complex collection of taste sensory cells,
supporting cells, and immature basal cells, is the structural unit for detecting taste stimuli in …

Patients with viral and bacterial infections or other inflammatory illnesses often experience
taste dysfunctions. The agents responsible for these taste disorders are thought to be related …

Taste disorders, including taste distortion and taste loss, negatively impact general health
and quality of life. To understand the underlying molecular and cellular mechanisms, we set …

Inflammatory cytokines are signaling molecules that regulate numerous physiological
processes, from tissue homeostasis to metabolism and food intake. Expression of certain …

The oral microbiome is second only to its intestinal counterpart in diversity and abundance,
but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found …

Inflammatory cytokines are important regulators of metabolism and food intake. Over
production of inflammatory cytokines during bacterial and viral infections leads to anorexia …

The sense of taste determines the choice of nutrients and food intake and, consequently,
influences feeding behaviors. The taste papillae are primarily composed of three types of …

Inflammation-mediated changes in taste perception can affect health outcomes in patients,
but little is known about the underlying mechanisms. In the present work, we hypothesized …