Synthesis, structural characterization and anticancer evaluation of pyrazole derivatives

MSA El-Gaby, MM Ghorab, ZH Ismail… - Medicinal Chemistry …, 2018 - Springer
The utility of 4-isothiocyanato-N-(1-phenyl-1 H-pyrazol-5-yl) benzene sulfonamide 2 in the
synthesis of some novel thiosemicarbazide, carbamothioate, 1, 3, 4-thiadiazole, azomethine …

Synthesis and antitumor activity of some novel pyrazole and thienopyrimidine derivatives

HM Aly - Phosphorus, Sulfur, and Silicon, 2009 - Taylor & Francis
The novel thiosemicarbazide derivative was prepared by hydrazinolysis of
isothiocyanatosulfonamide with hydrazine hydrate. It was used as a starting material for the …

Synthesis of some new pyrazole-based 1, 3-thiazoles and 1, 3, 4-thiadiazoles as anticancer agents

KM Dawood, TMA Eldebss, HSA El-Zahabi… - European journal of …, 2013 - Elsevier
Abstract N-(4-(Pyrazol-4-yl) thiazol-2-yl)-N′-phenylthiourea derivative 2 was synthesized
and then treated with variety of hydrazonoyl chlorides under basic condition at reflux to …

Synthesis, characterization and anticancer activity of some benzothiazole and thiazole derivatives

AY Hassan, M Sarg, E Husseiny - Journal of Advanced …, 2020 - aprh.journals.ekb.eg
Objective: This study aimed synthesis of benzothiazole and thiazole derivatives due to the
importance of these heterocycles as anticancer. Method: Novel benzothiazole and thiazole …

[PDF][PDF] Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine

AEM Abdallah, RM Mohareb, MHE Helal… - Acta Chimica …, 2021 - academia.edu
Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-
amine. The reactivity of the latter compound toward different chemical reagents was studied …

[PDF][PDF] Convenient synthesis, characterization, cytotoxicity and toxicity of pyrazole derivatives.

MM Kamel - Acta Chimica Slovenica, 2015 - pdfs.semanticscholar.org
Methyl-1H-pyrazol-5 (4H)-one (1) was used as a template to develop new anticancer
compounds and investigate their SAR. The ring modification of compound 1 occurred …

[PDF][PDF] Design, synthesis and anticancer screening of novel pyrazole derivatives linking to benzimidazole, benzoxazole and benzothiazole

MA Abdelgawad, KR Abdellatif, OM Ahmed - Med chem S, 2014 - academia.edu
Substituted aromatic amines were diazotized followed by coupling with malononitrile to
afford substituted phenyl hydrazono-malononitrile compounds 2a-c. Compounds 3a-c were …

[PDF][PDF] Synthesis of some novel thiazole, thiadiazole and 1, 4-phenylene-bis-thiazole derivatives as potent antitumor agents

SM Gomha, FM Abdelrazek… - …, 2016 - triggered.edina.clockss.org
A novel series of 2-ethylidenehydrazono-5-arylazothiazoles 5a-h and 2-
ethylidenehydrazono-5-arylazothiazolones 9a-d were prepared by cyclocondensation of …

Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents

SM Gomha, TA Salah, AO Abdelhamid - Monatshefte für Chemie …, 2015 - Springer
Abstract Two series of novel 2-[[1-(5-methyl-1-phenyl-5-substituted-1 H-pyrazol-4-yl)
ethylidene] hydrazono]-3-phenyl-2, 3-dihydro-1, 3, 4-thiadiazole derivatives and 2-[5-(4 …

[PDF][PDF] Synthesis and in vitro anticancer activity of 9-chloro-3-cyano-8-fluoro-2-methylthio-4-oxo-4H-pyrimido [2, 1-b][1, 3] benzothiazole and its 2-substituted …

PR Prasad, SD Shinde, GS Waghmare, VL Naik… - J Chem Pharm …, 2011 - academia.edu
The one pot synthesis of 9-chloro-3-cyano-8-fluoro-2-methylthio-4-oxo-4H-pyrimido [2, 1-
b][1, 3] benzothiazole (3) and its 2-substituted derivatives is convenient over traditional route …