Since the bactericidal effects of β-lactam antibiotics are time dependent, the optimum
strategy for their administration could be continuous infusion. In this prospective …

Background: The antibacterial effect of piperacillin/sulbactam depends on the time of drug
concentration above the minimal inhibitory concentration (MIC). Therefore, continuous …

Study Objective To determine whether critically ill patients receiving extended‐infusion (EI)
piperacillin/tazobactam would have improved clinical outcomes compared with patients …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

The aim of the present study was to evaluate the benefit of monitoring serum piperacillin
concentrations in critically ill patients. This was an 11-month, prospective, observational …

The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients
with microbiologically documented infections is currently unknown. We conducted a …

Purpose The purpose of this study is to review the rationale of prolonged (ie, extended or
continuous) infusion of piperacillin/tazobactam (PIP/TAZ) in critically ill patients and to …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with
intermittent bolus dosing standard therapy, despite a strong theoretical rationale for …