The pharmacodynamics and pharmacokinetics of ceftazidime administered by continuous
infusion and intermittent bolus over a 4-day period were compared. We conducted a …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Infections are common in critically ill patients and are associated with a significant increase
in ICU mortality and total costs related to patient management [1]. One of the main …

The clinical advantages of prolonged (extended/continuous) infusion remain controversial.
Previous studies and reviews have failed to show consistent clinical benefits of extending …

Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in
severe infections, because it provides a more stable free drug concentration and a longer …

Importance Whether β-lactam antibiotics administered by continuous compared with
intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective …

Objective: The clinical benefits of extended infusion or continuous infusion of β-lactam
antibiotics remain controversial. We systematically reviewed the literature to determine …

Introduction: Beta-lactams are at the cornerstone of therapy in critical care settings, but their
clinical efficacy is challenged by the rise in bacterial resistance. Infections with multi-drug …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

A prospective, randomized pilot study was undertaken to compare the efficacy of continuous
versus intermittent ceftazidime in ICU patients with nosocomial pneumonia. Ceftazidime was …