Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …

Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …

Background Administering β-lactam antibiotics via prolonged infusions for critically ill
patients is mainly based on preclinical evidence. Preclinical data on this topic have not been …

BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged
infusion of these agents is commonly performed to optimize the time the unbound …

Prolonged infusion of β-lactam antibiotics as either extended (over at least 2 hours) or
continuous infusion is increasingly applied in intensive care units around the world in an …

Background Extended infusion of beta-lactam antibiotics has been advocated as a method
for optimizing antibiotic exposure in critically ill patients. The objective of this study was to …

Piperacillin as a single agent was compared in a prospective randomized trial with
carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial …

Killing of bacteria by β-lactam antibiotics is maximal at around four times the minimum
inhibitory concentration in vitro. To ensure an optimal effect when treating severe infections …

Study Objective. To determine if continuous‐infusion ceftazidime is more cost‐effective and
efficacious than intermittent infusion in patients with nosocomial pneumonia. Design …