Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their
pancreatic islet cells. Whether the latter represents a primary defect or is a consequence of …

Abstract β-cell dysfunction is central to the onset and progression of type 2 diabetes.
Reduced islet number and/or diminished β-cell mass/volume in the pancreas of type 2 …

Recovery of functional β‐cell mass continues to be an ongoing challenge in treating
diabetes. Initial work studying β‐cells suggested apoptotic β‐cell death as a main contributor …

In 1960, immunoassays of insulin first demonstrated significant quantities of circulating
hormone in non-insulin-dependent (type II) diabetes and for 30 yr have fostered debate as to …

Type 2 diabetes mellitus (T2DM) results from pancreatic β‐cell failure in the setting of insulin
resistance. In the early stages of this disease, pancreatic β‐cells meet increased insulin …

Studies on the pathogenesis of type 1 diabetes have mainly focused on the role of the
immune system in the destruction of pancreatic beta-cells. Lack of data on the cellular and …

In vitro studies on purified rat beta cells have indicated a functional diversity among
insulincontaining cells. Intercellular differences were found in the rates of glucose-induced …

Type 2 diabetes is the most common form of diabetes in humans. It results from a
combination of factors that impair beta-cell function and tissue insulin sensitivity. However …

Insulin-deperrdent diabetes is the clinical consequence of a marked reduction in the number
of pancreatic beta cells. l In man, the disease is attributed to immune-mediated destruction of …

Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …