Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin
release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction …

Efforts to restore β-cell number or mass in type 1 diabetes (T1D) must combine an
intervention to stimulate proliferation of remaining β-cells and an intervention to mitigate or …

Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies
suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue …

In nondiabetic subjects, insulin secretion is sufficiently increased as a compensatory
adaptation to insulin resistance whereas in subjects with type 2 diabetes, the adaptation is …

Islet non-β-cells, the α-δ-and pancreatic polypeptide cells (PP-cells), are important
components of islet architecture and intercellular communication. In α-cells, glucagon is …

Abstract β-cell (beta-cell) impairment is central to the development and progression of
human diabetes, as a result of the combined effects of genetic and acquired factors …

For almost a century, diabetes research has focused on the endocrine pancreas and its
secretory products. This particular orientation started in 1889, after yon Meting and …

Context: Insulin resistance impacts virtually all tissues, including pancreatic β cells.
Individuals with insulin resistance, but without diabetes, exhibit an increased islet size …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by
pancreatic islet β cell loss and dysfunction resulting in insulin deficiency and hyperglycemia …

In healthy individuals, the ability of the pancreatic islets to sense and respond appropriately
to changes in plasma glucose levels maintains plasma glucose levels within a narrow range …