Targeting angiogenesis represents a new strategy for the development of anticancer
therapies. New targets derived from proliferating endothelial cells may be useful in …

Tumor angiogenesis is essential for the growth of primary and metastatic tumors. This
process requires the coordinated activities of multiple factors and cell types. For tumors to …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

Background Angiogenesis, the formation of new blood vessels from the endothelium of the
existing vasculature, is fundamental in tumor growth, progression, and metastasis. Inhibiting …

Angiogenesis is the process by which new blood vessels are formed from preexisting
microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic …

Angiogenesis is a complex process critical for embryonic development and for survival. It is
also a critical player in many pathologic processes, most notably in neoplasia. The cell …

A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Angiogenesis is regulated by the balance of pro-angiogenic factors and angiogenesis
inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis …