Organic acids (OAs) play important roles in a variety of intracellular metabolic pathways,
such as the tricarboxylic acid cycle, fatty acid oxidation, glycolysis. The accurate detection of …

A sensitive, accurate and precise method was developed for the quantification of a large
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …

Abstract Metabolomics, a 'budding'discipline, may accurately reflect a specific phenotype
which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in …

Organic acid (OA) analysis is a specific test for inherited metabolic disorders (IMDs);
however, the previous detection methods are laborious and costly. This study aims to …

A simple and selective ultrahigh-performance liquid chromatographic-Orbitrap mass
spectrometric (UHPLC-HR-MS) method was developed and validated for the simultaneous …

Gas chromatography-mass spectrometry has been widely used to analyze hundreds of
organic acids in urine to provide a diagnostic basis for organic acidemia. However, it is …

Short-chain fatty acids (SCFAs) are carboxylic acids that contain fewer than six carbons and
are the metabolites of the intestinal flora. SCFAs participate in almost all circulatory system …

Rationale Low‐molecular‐weight organic acids that generally contain one to three carboxyl
groups are involved in many important biological processes; therefore, it is important to …

Short-chain fatty acids (SCFAs) play key roles in maintaining health and treating disease.
Quantification of important fecal SCFAs is necessary to facilitate the clarification of their …

The quantification of short-chain and medium-chain fatty acids is becoming more and more
relevant in fecal and plasma samples due to their biological impact, which has been …