Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report
M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Circulating lipoprotein (a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses
Abstract Background Lipoprotein (a)[Lp (a)] is a risk factor for atherosclerotic and valvular
diseases, but its possible role in other diseases has not yet been established. We conducted …
diseases, but its possible role in other diseases has not yet been established. We conducted …
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
Phenotypic characterization of genetically lowered human lipoprotein (a) levels
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
Lipoprotein (a) is markedly more atherogenic than LDL: an apolipoprotein B-based genetic analysis
E Björnson, M Adiels, MR Taskinen, S Burgess… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) is recognized as a causal factor for coronary
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …
(a) levels in African Americans (AAs) are much higher compared with that in European …
Associations of genetically predicted Lp (a)(lipoprotein [a]) levels with cardiovascular traits in individuals of European and African Ancestry
Background: Lp (a)(lipoprotein [a]) levels are higher in individuals of African ancestry (AA)
than in individuals of European ancestry (EA). We examined associations of genetically …
than in individuals of European ancestry (EA). We examined associations of genetically …
Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …