Cardiac repair following ischemic injury is indispensable for survival and requires a
coordinated cellular response involving the mobilization of immune cells from the secondary …

Clearance of dying cells by efferocytosis is necessary for cardiac repair after myocardial
infarction (MI). Recent reports have suggested a protective role for vascular endothelial …

The mammalian heart contains a population of resident macrophages that expands in
response to myocardial infarction through the recruitment of monocytes. Infarct …

As an integral component of cardiac tissue, macrophages are critical for cardiac
development, adult heart homeostasis, as well as cardiac healing. One fundamental function …

Coronary revascularization is an effective means of treating ischemic heart disease;
however, current therapeutic revascularization strategies are limited to large caliber vessels …

Efferocytosis, mediated by the macrophage receptor MerTK (myeloid‐epithelial‐
reproductive tyrosine kinase), is a significant contributor to cardiac repair after myocardial …

Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages
(collectively termed efferocytosis) is critical for inflammation resolution and restoration of …

Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …

It is well established that maladaptive innate immune responses to sterile tissue injury
represent a fundamental mechanism of disease pathogenesis. In the context of cardiac …

The efficient phagocytic clearance of dying cells and apoptotic cells is one of the processes
that is essential for the maintenance of physiologic tissue function and homeostasis, which is …