Burn injury-induced pain (BIP) is an extremely complicated condition usually resistant to
analgesic drugs, while its pathogenesis remains unknown. Considerable attention has been …

Exposure to chronic stress can produce maladaptive neurobiological changes in pathways
associated with pain processing, which may cause stress–induced hyperalgesia (SIH) …

Purpose Corticotropin-releasing hormone (CRH) plays an important role in relief of pain by
releasing analgesia-associated molecules in several inflammatory states. During …

It has been widely accepted that the primary somatosensory cortex (SI) plays an essential
role in the sensory-discriminative aspect of pain perception. However, it remains unclear …

Object Central neuropathic pain is a frequent challenging complication after spinal cord
injury (SCI), and specific therapeutic approaches remain elusive. The purpose of the present …

Clinical data have shown that chronic exposure to stress may be accompanied by an
enhancement of inflammation-related pain sensitivity. In this context, little is however known …

The pathological mechanisms of fibromyalgia (FM) are largely unknown. Recently, a rat
reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical …

We have studied scalding-type burn injury-induced activation of extracellular signal-
regulated kinase 1/2 (ERK1/2) in the spinal dorsal horn, which is a recognised marker for …

Background Under the condition of stress, the hypothalamic–pituitary–adrenal axis (HPA
axis) is activated and causes the secretion of corticotropin‐releasing factor (CRF). Previous …

Repeated cold stress (RCS) is known to transiently induce functional disorders associated
with hypotension and hyperalgesia. In this study, we investigated the effects of RCS (24 and …