Individual differences in pain sensitivity and reactivity are well recognized but the underlying
mechanisms are likely to be diverse. The phenomenon of stress-induced analgesia is well …

Background CRPS is a painful, debilitating, and often-chronic condition characterized by
various sensory, motor, and vascular disturbances. Despite many years of study, current …

Migraine represents one of the major causes of disability worldwide and is more prevalent in
women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently …

Background Under the condition of stress, the hypothalamic–pituitary–adrenal axis (HPA
axis) is activated and causes the secretion of corticotropin‐releasing factor (CRF). Previous …

Background: Fibromyalgia (FM) is characterized by chronic widespread pain, which is often
refractory to conventional painkillers. Numerous clinical studies have demonstrated that …

Neuropathic pain is associated with persistent changes in gene expression in primary
sensory neurons, but the underlying epigenetic mechanisms that cause these changes …

Neuropeptide FF (NPFF) is recognized as an opioid modulating peptide that regulates
morphine-induced analgesia. The aim of this study was to delineate the role of NPFFR2 in …

Background Pain is one critical hallmark of inflammatory responses. A large number of
studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as …

The corticotropin-releasing factor (CRF) is involved in a number of physiological functions
including pain perception. The purpose of this study was to evaluate the role of CRF1 …

Background Under inflammatory conditions, the activation of corticotropin-releasing factor
(CRF) receptor has been shown to inhibit pain through opioid peptide release from immune …