Src family of kinases (SFKs) has been found to play an important role in the regulation of
nociception. However, how each member of this family acts in the central nervous system …

Clinical evidence suggests that vitamin C (Vit C) may protect against the development of
complex regional pain syndrome (CRPS) after fracture or surgery. Tibia fracture followed by …

Peripheral glucocorticoid receptors (GRs) play a significant role in the anti-inflammatory
effects of glucocorticoids; however, the role of central GRs in nociceptive behaviors after …

Spinal cord injury (SCI) is a complex syndrome that has profound effects on patient well-
being, including the development of medically-resistant chronic pain. The mechanisms …

Three experiments were conducted to test the hypothesis that brain corticotropin-releasing
hormone (CRH) systems mediate stress-induced freezing behavior, an index of a rat's level …

Background: Pulsed radiofrequency (PRF) therapy is a clinical treatment utilizing
electromagnetic energy aimed to relieve neuropathic pain. This is the first study examining …

Background: Regulation of pain states is, in part, dependent upon plastic changes in
neurones within the superficial dorsal horn. There is also compelling evidence that pain …

Background Currently, there is a lack of effective therapy for chronic pain. Increasing
evidence has shown that chemokines and their correlative receptors involved in the neuron …

Emerging evidence has indicated that colony-stimulating factor-1 (CSF1) modulates
neuroinflammation in the central nervous system and the development of neuropathic pain …

Inflammatory cytokines contribute to lumbar radiculopathy. Regulation of cytokines for
transient cervical injuries, with or without longer-lasting inflammation, remains to be defined …