Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Y Li, THW Huang, J Yamahara - Life sciences, 2008 - Elsevier
In many traditional schools of medicine it is claimed that a balanced modulation of several
targets can provide a superior therapeutic effect and decrease in side effect profile …

Quantitative determination of potent α-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography–mass spectrometry

O Muraoka, T Morikawa, S Miyake, J Akaki… - … of pharmaceutical and …, 2010 - Elsevier
A practical HPLC–MS method for the quantitative determination of salacinol (1) and
kotalanol (2), potent α-glucosidase inhibitors from Salacia species (Hippocrateaceae) as a …

Safety evaluation of an extract from Salacia oblonga

BW Wolf, SE Weisbrode - Food and chemical toxicology, 2003 - Elsevier
Plant extracts from the Salacia genus have been found to have intestinal α-glucosidase
inhibitor activity, which may have application to the development of medical foods for people …

Antidiabetic principles of natural medicines. IV. Aldose reductase and α-glucosidase inhibitors from the roots of Salacia oblonga Wall.(Celastraceae): structure of a …

H Matsuda, T Murakami, K Yashiro… - Chemical and …, 1999 - jstage.jst.go.jp
抄録 The aqueous methanolic extract of an Indian natural medicine, the roots of Salacia
oblonga WALL.(Celastraceae), was found to show inhibitory activity on the increase in …

Three new triterpenoids from Salacia hainanensis Chun et How showed effective anti-α-glucosidase activity

J Huang, Z Guo, P Cheng, B Sun, HY Gao - Phytochemistry Letters, 2012 - Elsevier
To identify the chemical constituents with hypoglycemic activity in Salacia hainanensis Chun
et How, this study was carried out on the roots of S. hainanensis. By means of a bioassay …

Synthesis of salacinol

H Yuasa, J Takada, H Hashimoto - Tetrahedron Letters, 2000 - Elsevier
Salacinol, a new type of α-glucosidase inhibitor discovered from the antidiabetic herb, was
synthesized for the first time. Under the strategy that salacinol would be synthesized by the …

Structures of Steroidal Alkaloid Oligoglycosides, Robeneosides A and B, and Antidiabetogenic Constituents from the Brazilian Medicinal Plant Solanum lycocarpum

M Yoshikawa, S Nakamura, K Ozaki… - Journal of natural …, 2007 - ACS Publications
In the course of our studies on antidiabetogenic compounds from natural medicines and
medicinal foodstuffs, a methanolic extract of the fruits of Solanum lycocarpum showed an …

Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography

O Muraoka, T Morikawa, S Miyake, J Akaki… - Journal of natural …, 2011 - Springer
A quantitative analytical method for the highly polar sulfonium pseudo-sugar constituents
neosalacinol (3) and neokotalanol (4), another two potent α-glucosidase inhibitors isolated …

Naturally occurring sulfonium-ion glucosidase inhibitors and their derivatives: a promising class of potential antidiabetic agents

S Mohan, R Eskandari, BM Pinto - Accounts of chemical research, 2014 - ACS Publications
In humans, four different enzymes mediate the digestion of ingested carbohydrates. First
salivary and pancreatic α-amylases, the two endoacting retaining glucosidases, break down …

Sulfonium-ion glycosidase inhibitors isolated from Salacia species used in traditional medicine, and related compounds

S Mohan, BM Pinto - Collection of Czechoslovak Chemical …, 2009 - cccc.uochb.cas.cz
A novel class of naturally-occurring glycosidase inhibitors, having sulfonium sulfate
structures, has been isolated as bioactive components from Indian plants, belonging to the …