Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …

The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is
unexplained. One factor may be the low frequency and immature phenotype of virus-specific …

Abstract The CD4+ CD25+ regulatory T lymphocytes have been implicated in suppressing T
cell immune responses. Our aim was to characterize the frequency, phenotype, function, and …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

The cellular immune response contributes to clearance of hepatitis C virus (HCV) and
persists for decades after recovery from infection. The immunological basis for the …

Regulatory T (TR) cells consist of phenotypically and functionally distinct CD4+ and CD8+ T
cell subsets engaged both in maintaining self-tolerance and in preventing anti–non-self …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

Summary CD4+ CD25+ T regulatory cells may play a role in the different clinical
presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell …

BACKGROUND & AIMS: Virus-specific CD8+ T cells are required for the control of hepatitis
C virus (HCV) infection. We investigated the extent to which different effector functions of …