In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

Y Itoh, T Kuratsuji, S Tsunawaki, S Aizawa… - International Journal of …, 1991 - europepmc.org
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing
clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in …

Effects of recombinant human granulocyte colony-stimulating factor on neutrophil function in normal rats.

T Yoshino, M Tamura, K Hattori… - International Journal …, 1991 - europepmc.org
We studied the effects of recombinant human granulocyte colony-stimulating factor (rG-CSF)
on neutrophil functions in vitro using neutrophils isolated from the venous blood of normal …

In vivo administration of granulocyte colony‐stimulating factor promotes neutrophil survival in vitro

S Adachi, M Kubota, YW Lin, A Okuda… - European journal of …, 1994 - Wiley Online Library
We recently showed that recombinant human granulocyte‐colony stimulating factor (rhG‐
CSF) maintained the viability of human neutrophils in incubation for up to 72 hours …

Effects of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) on neutrophil kinetics and function in normal human volunteers

DC Dale, WC Liles, C Llewellyn… - American journal of …, 1998 - Wiley Online Library
Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)(250 μg/m2) was
administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on …

Effects of recombinant human granulocyte colony-stimulating factor administration on neutrophil phenotype and functions

G Carulli - Haematologica, 1997 - haematologica.org
BACKGROUND AND OBJECTIVE: Recombinant human granulocyte colony-stimulating
factor (rhG-CSF) is currently used for treatment of various types of neutropenia, treatment of …

Granulocyte colony‐stimulating factor administration modulates the surface expression of effector cell molecules on human monocytes

A Ohsaka, K Saionji, T Kuwaki… - British journal of …, 1995 - Wiley Online Library
Granulocyte colony‐stimulating factor (G‐CSF) has been shown to stimulate human
neutrophil functions, both in vitro and in vivo. We examined the effects of G‐CSF …

Pharmacokinetics and pharmacodynamics of recombinant human granulocyte-colony stimulating factor after intravenous and subcutaneous administration in the rat.

H Tanaka, Y Okada, M Kawagishi, T Tokiwa - Journal of Pharmacology and …, 1989 - ASPET
The pharmacokinetics of recombinant human granulocyte-colony stimulating factor (rhG-
CSF)(produced by Kirin Brewery Co., Ltd.) in sera was studied after iv and sc administration …

Pharmacokinetic/pharmacodynamic analysis of neutrophil proliferation induced by recombinant granulocyte colony-stimulating factor (rhG-CSF): comparison between …

M Sugiura, K Yamamoto, Y Sawada… - Biological and …, 1997 - jstage.jst.go.jp
抄録 Pharmacological effect after intravenous (iv) or subcutaneous (sc) administration of
human recombinant granulocyte colony stimulating factor (rhG-CSF) was evaluated by using …

Granulocyte colony‐stimulating factor (G‐CSF) induces the production of cytokines in vivo

S Xu, M Höglund, L Håkansson… - British journal of …, 2000 - Wiley Online Library
Granulocyte colony‐stimulating factor (G‐CSF) is a haematopoietic growth factor required
for the proliferation and differentiation of haematopoietic precursors of neutrophil …

Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans

TH Price, GS Chatta, DC Dale - 1996 - ashpublications.org
Recombinant granulocyte colony-stimulating factor (G-CSF) was administered to healthy
young (n= 32) and elderly (n= 19) volunteers (0 microgram/d, 30 microgram/d, or 300 …