Objectives Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug
resistance is slow and unreliable, limiting individualized therapy and monitoring of national …

Background: Whole-genome sequencing (WGS) is a viable and financially feasible tool for
timely and comprehensive diagnosis of drug resistance in developed countries. With the …

Whole-genome sequencing (WGS) has shown tremendous potential in rapid diagnosis of
drug-resistant tuberculosis (TB). In the current study, we performed WGS on drug-resistant …

Defining the precise relationship between resistance mutations and quantitative phenotypic
drug susceptibility testing will increase the value of whole-genome sequencing (WGS) for …

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis
(MTB). Whole-genome sequencing (WGS) holds great promise as an advanced technology …

Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

Background The emergence of resistance to anti-tuberculosis drugs is a serious and
growing threat to public health. Next-generation sequencing is rapidly gaining traction as a …

Whole-genome sequencing allows rapid detection of drug-resistant Mycobacterium
tuberculosis isolates. However, the availability of high-quality data linking quantitative …

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

Drug-resistant tuberculosis (DR-TB) posed challenges to global TB control. Whole-genome
sequencing (WGS) is recommended for predicting drug resistance to guide DR-TB treatment …