Immune responses must be rapid, tightly orchestrated, and tailored to the encountered
stimulus. Lymphatic vessels facilitate this process by continuously collecting immunological …

The lymph node (LN) is a vital organ of the lymphatic and immune system that enables
timely detection, response, and clearance of harmful substances from the body. Each LN …

Lymph nodes (LNs) are at the cross roads of immunity and tolerance. These tissues are
compartmentalized into specialized niche areas by lymph node stromal cells (LN SCs). LN …

Following immunization, lymph nodes dynamically expand and contract. The mechanical
and cellular changes enabling the early-stage expansion of lymph nodes have been …

Leukocyte egress from peripheral tissues to draining lymph nodes is not only critical for
immune surveillance and initiation but also contributes to the resolution of peripheral tissue …

T‐cell responses are initiated within secondary lymphoid organs, and effector T‐cells are
released into the circulation where they home to inflamed tissues and mediate protective …

The spatial and temporal Ag distribution determines the subsequent T cell and B cell
activation at the distinct anatomical locations in the lymph node (LN). It is well known that LN …

Biomaterial vaccines offer cargo protection, targeting, and co-delivery of signals to immune
organs such as lymph nodes (LNs), tissues that coordinate adaptive immunity …

Recent intravital microscopy experiments have revealed the complex behavior of T cells
within lymph nodes. Modeling T‐cell responses in lymph nodes now requires integration of …

The immune system is a multicentered organ that is characterized by intimate interactions
between its cellular components to efficiently ward off invading pathogens. A key constituent …