Anatomical strategies that help cells to interact greatly increase the efficiency of the adaptive
immune system. In vivo, antigens are presented in a complex environment, wherein their …

The microenvironment of lymphoid organs can aid healthy immune function through
provision of both structural and molecular support. In mice, fibroblastic reticular cells (FRCs) …

B and T cells, with their extremely diverse antigen-receptor repertoires, have the ability to
mount specific immune responses against almost any invading pathogen1, 2 …

Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …

Adaptive immune response consists of many highly regulated, multistep cascades that
protect against infection while preserving the health of autologous tissue. The proper …

Reactive lymph nodes (LNs) are sites where pMHC-loaded dendritic cells (DCs) interact
with rare cognate T cells, leading to their clonal expansion. While DC interactions with T cell …

The spleen is involved in fluid volume regulation, immune responses, and hematopoiesis.
Yet, the composition of the fluid phase within the spleen microenviroment, the migratory …

Activation of T cells by antigen‐presenting cells (APCs) in lymph nodes (LNs) is a key
initiating event in many immune responses. Our understanding of this process has been …

Organ-specific lymphatics are essential for the maintenance of healthy organ function and
lymphatic dysfunction can lead to the development of various diseases. However, the …

Mounting a protective immune response is critically dependent on the orchestrated
movement of cells within lymphoid tissues. The structure of secondary lymphoid organs …