Immense progress in microscale engineering technologies has significantly expanded the
capabilities of in vitro cell culture systems for reconstituting physiological microenvironments …

Lymphoid tissues are found in all vertebrates and are essential for adaptive immunity.
Primary lymphoid tissues (thymus, fetal liver and bone marrow) nurture lymphocyte …

Understanding cellular processes occurring in vivo on time scales of days to weeks requires
repeatedly interrogating the same tissue without perturbing homeostasis. We describe a …

The promising results point to powerful techniques to harness the lymph node
microenvironment and direct systemic immune regulation. The materials, techniques, and …

The induction of an adaptive immune response is an essential step in the generation of long-
lasting, protective immunity to pathogens. Many studies over the last few decades have …

Lymphatic vessels provide a critical line of communication between peripheral tissues and
their draining lymph nodes, which is necessary for robust immune responses against …

The intestinal immune system plays an essential role in maintaining the barrier function of
the gastrointestinal tract by generating tolerant responses to dietary antigens and …

Recently developed approaches for highly multiplexed imaging have revealed complex
patterns of cellular positioning and cell-cell interactions with important roles in both cellular …

The adaptive immune response is initiated in secondary lymphoid organs by contact
between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+ T cells. However …

Lymph nodes (LNs) are constructed of intricate networks of endothelial and mesenchymal
stromal cells. How these lymphoid stromal cells (LSCs) regulate lymphoid tissue remodeling …