A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key
aspects of their biology remain poorly elucidated. Here, comparative transcriptomic analyses …

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper
T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s …

T cell immune responses begin within organized lymphoid tissues. The pace, topology, and
outcomes of the cellular interactions that underlie these responses have, so far, been …

A critical hallmark of adaptive immune responses is the rapid and extensive expansion of
lymph nodes. During this process, the complex internal structure of the organs is maintained …

During inflammation, accumulation of immune cells in activated lymph nodes (LNs), coupled
with a transient shutdown in lymphocyte exit, results in dramatic cellular expansion. Counter …

Emergent physical properties of tissues are not readily understood by reductionist studies of
their constituent cells. Here, we show molecular signals controlling cellular, physical, and …

Lymphocytes continuously patrol the secondary lymphoid organs (SLOs) of mammals in
search for their cognate antigens. SLOs are composed of leucocytes (~ 95%) and lymphoid …

Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic
progression in breast cancer, where a correlation between the occurrence of lymph node …

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and
in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models …