Hypoxia elicits a variety of adaptive responses at the tissue level, at the cellular level, and at
the molecular level. A physiological response to hypoxia requires the existence of an O2 …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Mitochondrial respiration is responsible for more than 90% of oxygen consumption in
humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of …

All eukaryotic cells utilize oxidative phosphorylation to maintain their high‐energy
phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and …

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor …

There are numerous mechanisms by which mammals respond to hypoxia. These include
acute changes in pulmonary arterial tone due to smooth muscle cell contraction, acute …

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The
transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis …

Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently
accepted signaling paradigm is that the mitochondrial generation of reactive oxygen species …

Physiological hypoxia results in a host of responses that include increased ventilation,
constriction of the pulmonary artery, and a cellular transcriptional program that promotes …

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years …