Mitochondria are confronted with low oxygen levels in the microenvironment within tissues;
yet, isolated mitochondria are routinely studied under air-saturated conditions that are …

During myocardial hibernation, decreases in coronary perfusion elicit inhibition of
contraction, suggesting that energy demand is attenuated. We previously found an inhibition …

Mitochondria are frequently the target of injury after stresses leading to necrotic and
apoptoticcell death. Inhibition of oxidative phosphorylation progresses to uncoupling when …

Multicellular organisms initiate adaptive responses when oxygen (O 2) availability
decreases, but the underlying mechanism of O 2 sensing remains elusive. We find that …

Transcriptional activation of erythropoietin, glycolytic enzymes, and vascular endothelial
growth factor occurs during hypoxia or in response to cobalt chloride (CoCl2) in Hep3B …

Normal cellular physiology is critically dependent on numerous mitochondrial activities
including energy conversion, cofactor and precursor metabolite synthesis, and regulation of …

In anoxia, mitochondria change from being ATP producers to potentially powerful ATP
consumers. This change occurs, because the mitochondrial F1F0-ATPase begins to …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

Structural and functional integrity of organ function profoundly depends on a regular oxygen
and glucose supply. Any disturbance of this supply becomes life threatening and may result …

The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …