WNT–β-catenin signalling—a versatile player in kidney injury and repair

SJ Schunk, J Floege, D Fliser, T Speer - Nature Reviews Nephrology, 2021 - nature.com
The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

[HTML][HTML] Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword

D Zhou, RJ Tan, H Fu, Y Liu - Laboratory investigation, 2016 - Elsevier
The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Wnt/β-catenin in acute kidney injury and progression to chronic kidney disease

T Huffstater, WD Merryman, LS Gewin - Seminars in nephrology, 2020 - Elsevier
Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the
development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI …

Wnt signaling in kidney development and disease

Y Wang, CJ Zhou, Y Liu - Progress in molecular biology and translational …, 2018 - Elsevier
Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

[HTML][HTML] Wnt/β-catenin signaling and kidney fibrosis

RJ Tan, D Zhou, L Zhou, Y Liu - Kidney international supplements, 2014 - Elsevier
Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

Wnt signalling in kidney diseases: dual roles in renal injury and repair

T Kawakami, S Ren, JS Duffield - The Journal of pathology, 2013 - Wiley Online Library
Wnt signalling is a complex, highly conserved, cell‐to‐cell communication pathway in
multicellular organisms, regulating cell fate, function and phenotype in development, and …

New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis

Y Zuo, Y Liu - Nephrology, 2018 - Wiley Online Library
Wnt/β‐catenin is an evolutionarily conserved, developmental signalling pathway that
regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated …

[HTML][HTML] Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

D Wang, C Dai, Y Li, Y Liu - Kidney international, 2011 - Elsevier
Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney
diseases and is associated with podocyte injury and proteinuria; however, the mechanisms …

[HTML][HTML] Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling

D Song, J Shang, Y Long, M Zhong, L Li, J Chen… - Jci Insight, 2023 - ncbi.nlm.nih.gov
Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …

Sustained activation of Wnt/β-catenin signaling drives AKI to CKD progression

L Xiao, D Zhou, RJ Tan, H Fu, L Zhou… - Journal of the …, 2016 - journals.lww.com
AKI is increasingly recognized as a major risk factor for progression to CKD. However, the
factors governing AKI to CKD progression are poorly understood. In this study, we …