Every year nearly 6 percent of children worldwide are born with a serious congenital
malformation, resulting in death or lifelong disability. In the United States, birth defects …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …

Neural tube defects (NTDs) are a heterogeneous set of malformations attributed to
disruption in normal neural tube closure during early embryogenesis. An in‐depth …

The developing mammalian nervous system is subject to devastating congenital
malformations with clinical significance that extends into the billions of health care dollars …

BACKGROUND Neural tube closure is a critical embryological process that requires the
coordination of many molecular and cellular events. Only recently has the molecular basis of …

Background Neural tube defects (NTD) are among the most common defects affecting 1:
1000 births. They are caused by a failure of neural tube closure during development. Their …

Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …

Neural tube defects (NTDs) are common birth defects resulting from failure of the neural
epithelium (primordium of the brain and spinal cord) to form a tube. In a tightly regulated …

Neural tube defects (NTDs) are among the most common structural birth defects observed in
humans. Mouse models provide an excellent experimental system to study the underlying …