Adenosine receptors as potential therapeutic targets

SM Kaiser, RJ Quinn - Drug discovery today, 1999 - Elsevier
Recent studies indicate a widening role for adenosine receptors in many therapeutic areas.
Adenosine receptors are involved in immunological and inflammatory responses, respiratory …

Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Adenosine and adenosine receptors: newer therapeutic perspective

S Manjunath, PM Sakhare - Indian journal of pharmacology, 2009 - journals.lww.com
Adenosine, a purine nucleoside has been described as a'retaliatory metabolite'by virtue of
its ability to function in an autocrine manner and to modify the activity of a range of cell types …

Pharmacology of adenosine receptors: Recent advancements

F Vincenzi, S Pasquini, C Contri, M Cappello, M Nigro… - Biomolecules, 2023 - mdpi.com
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Adenosine receptors in health and disease

S Gessi, S Merighi, K Varani, PA Borea - Advances in pharmacology, 2011 - Elsevier
The adenosine receptors A 1, A 2A, A 2B, and A 3 are important and ubiquitous mediators of
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …

Adenosine receptors as therapeutic targets

KA Jacobson, ZG Gao - Nature reviews Drug discovery, 2006 - nature.com
Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Adenosine receptor targeting in health and disease

S Gessi, S Merighi, D Fazzi, A Stefanelli… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: The adenosine receptors A1, A2A, A2B and A3 are important and ubiquitous
mediators of cellular signaling that play vital roles in protecting tissues and organs from …

Adenosine receptors: what we know and what we are learning

ML Trincavelli, S Daniele… - Current topics in medicinal …, 2010 - ingentaconnect.com
Adenosine, beside its role in the intermediate metabolism, mediates its physiological
functions by interacting with four receptor subtypes named A1, A2A, A2B and A3. All these …

Adenosine receptor agonists

MA Jacobson - Expert Opinion on Therapeutic Patents, 2002 - Taylor & Francis
Adenosine, a naturally-occurring nucleoside, modulates a variety of physiological and
pathophysiological processes. The effects of adenosine are mediated via a family of cell …

International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …