Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in
humans and mice result in loss of both the white and brown adipose tissues from birth …

Revised Manuscript Received June 1, 19939 abstract: Glycerol-3-phosphate acyltransferase
(GPAT) catalyzes the initial and committed step in glycerolipid biosynthesis. Mitochondrial …

Although triacylglycerol stores play the critical role in an organism's ability to withstand fuel
deprivation and are strongly associated with such disorders as diabetes, obesity, and …

The conversion of lysophosphatidic acid (LPA) to phosphatidic acid is carried out by the
microsomal enzymes 1-acylglycerol-3-phosphate-O-acyltransferases (AGPATs). These …

The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the
activities of triacylglycerol lipases. In this study, we demonstrate that adipose triglyceride …

Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions …

In vitro studies suggest that the mitochondrialglycerol-3-phosphate acyltransferase-1
(mtGPAT1) isoform catalyzes the initialand rate-controlling step in glycerolipid synthesis and …

Phosphatidylglycerol (PG) is an important membrane polyglycerolphospholipid required for
the activity of a variety of enzymes and is a precursor for synthesis of cardiolipin and bis …

The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts
lysophosphatidic acid (LPA) to phosphatidic acid (PA). In this study, we show enzymatic …

The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG).
Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of …