Abstract AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of
lysophosphatidic acid to form phosphatidic acid (PA), a key step in the glycerol-3-phosphate …

▪ Abstract The activities of critical enzymes in fatty acid and triacylglycerol biosynthesis are
tightly controlled by different nutritional, hormonal, and developmental conditions. Feeding …

One of the central reactions in bodily energy metabolism is lipolysis in adipocytes, the
reaction that governs the release of stored fatty acids from the adipocyte triacylglycerol pool …

Fatty liver is commonly associated with insulin resistance and type 2 diabetes, but it is
unclear whether triacylglycerol accumulation or an excess flux of lipid intermediates in the …

Triacylglycerol (TAG) is an important product in oil-producing organisms. Biosynthesis of
TAG can be completed through either esterification of fatty acids to glycerol backbone, or …

Glycerol-3-phosphate acyltransferase (GPAT) catalyses the first committed step in
glycerolipid biosynthesis. The mitochondrial isoform (mtGPAT) is mainly expressed in liver …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty
acids to a glycerol backbone, with unique enzymes required to catalyze each acylation step …

Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis
through the conversion of phosphatidate to diacylglycerol, the immediate precursor of …

Fatty acids (FAs) are essential components of all lipid classes and pivotal substrates for
energy production in all vertebrates. Additionally, they act directly or indirectly as signaling …